Dr. G explains how common NSAIDs (ibuprofen, naproxen, celecoxib, etc.) can interfere with the wound-healing process in people with diabetes by blocking prostaglandins, delaying fibroblast recruitment, reducing angiogenesis and collagen deposition, and increasing TNF-alpha—leading to stalled ulcers and higher infection risk.

The episode reviews safer pain-management alternatives (acetaminophen, topical agents, neuropathic medications, physical therapy, supplements) and gives practical clinical advice: avoid long-term NSAID use for chronic diabetic wounds, educate patients, and use team-based strategies to protect healing while treating pain.