Sam (Jared Padalecki) and Dean (Jensen Ackles) get a call from Annie Hawkins (guest star Jamie Luner), an old hunter friend, asking for help on a case. When they arrive in town, they find out Annie has disappeared. They trace her last whereabouts to an old abandoned house that is haunted by a powerful ghost. Tim Andrew directed the episode written by Brad Buckner & Eugenie Ross-Leming (#719).