Since 2020, Africa has witnessed a resurgence of yellow fever. In this episode, we explore the reasons behind this surge and the measures being taken to combat it. We hear a comprehensive overview of the yellow fever situation across the continent, from Dr Charles Shey Wiysonge, Team Leader for Vaccine-Preventable Diseases at the WHO’s Regional Office for Africa, examining factors such as vaccine hesitancy, post-Covid immunisation gaps, and population movement. We also hear from Dr. Antoinette Mbailamen Demian, Director of Immunisation at the Ministry of Health in Chad, about how her country is managing the influx of refugees from Sudan and tackling recent outbreaks.