Harry Gordon, a struggling vaudeville comic, is famous for one thing: his laugh — loud, high-pitched, and uncontrollable. It's his signature… and his curse. Once wildly popular, Harry’s career is now fading, and he’s become bitter, paranoid, and dangerously desperate for a comeback.

When a rival comic drops dead during a live performance — literally laughing himself to death — Harry becomes both a suspect… and a star.