In this episode of Daily Value, we look at the relationship between genetics, habitual caffeine intake, and cognitive performance, using insights from a recent study (PMID: 39648354) in the Journal of Psychopharmacology. Whether you’re a "fast" or "slow" caffeine metabolizer could significantly influence how caffeine impacts your brain.

Discussion Points:

• Gene-Caffeine Interactions: how variants in CYP1A2 and ADORA2A genes modulate caffeine metabolism and sensitivity, leading to differential effects on executive function and social cognition.
• Cognitive Domains: Why slow metabolizers consuming high caffeine outperform fast metabolizers in emotion recognition tasks, and why moderate caffeine enhances executive function in fast metabolizers.
• Practical Applications: Tailoring caffeine intake based on genetic predisposition to optimize focus, decision-making, and cognitive flexibility.

https://pubmed.ncbi.nlm.nih.gov/39648354/