The U.S. National Science Foundation's Zettawatt-Equivalent Ultrashort pulse laser System (ZEUS) is the highest power laser system in the United States, providing world-leading capabilities for scientific, medical, defense and industrial research. We are joined by Karl Krushelnick, professor of nuclear engineering and radiological sciences and director of the Gérard Mourou Center for Ultrafast Optical Science at the University of Michigan, which houses ZEUS, to hear about how the laser works, the research that will be conducted there, and how extreme light interacts with different materials.