This Nature review article explores the evolving understanding of type 2 immunity, traditionally associated with defense against parasitic infections and tissue repair. The authors, Marek Wagner, Hiroyoshi Nishikawa, and Shigeo Koyasu, challenge the conventional view that type 2 immunity exclusively promotes tumor growth. Instead, they highlight emerging evidence suggesting its potential role in suppressing or protecting against cancer. The review also examines how these new insights could lead to innovative cancer immunotherapies, emphasizing the nuanced and complex interplay between the immune system and cancer progression.

References:

• Wagner, M., Nishikawa, H. & Koyasu, S. Reinventing type 2 immunity in cancer. Nature 637, 296–303 (2025). doi.org