This study identifies a neuroimmune loop linking the heart and brain after myocardial infarction. The circuit involves sensory vagus neurons, the hypothalamic paraventricular nucleus, and the superior cervical ganglia. Interrupting this loop reduces inflammation and scarring.

References:

• Yadav S, Ninh V K, Lovelace J W, et al. A triple-node heart-brain neuroimmune loop underlying myocardial infarction[J]. Cell, 2026, 189(3): 800-817. e20.

Researchers used a yeast-based SPS system to identify atazanavir as a pan-PAM for family A GPCRs. It acts as a molecular glue, stabilizing a non-canonical megacomplex through pendulum engagement of β-arrestin, leading to sustained G protein signaling from endosomes.

References:

• He G, Sun Q, Xu X, et al. A GPCR-G protein-β-arrestin megacomplex enabled by a versatile allosteric modulator[J]. Cell, 2026.

Research identifies low-gamma power in the anteromedial orbitofrontal cortex (amOFC) as a biomarker for OCD distress. Stimulating the ventral basal ganglia (NAc-VeP) reduces this neural activity and alleviates symptoms, supporting personalized, closed-loop deep brain stimulation.

References:

• Nho Y H, Qiu L, Seilheimer R L, et al. Human orbitofrontal neural activity is linked to obsessive-compulsive behavioral dynamics[J]. Cell, 2026.

thought Plants utilize systemic stomatal immunity (SSIM) to rapidly close stomata in distal leaves upon local infection. The mobile signal USIC, an uORF-encoded peptide, travels via the phloem to be sensed by the SIRK1-KIN7 receptor complex, triggering MC4-mediated cleavage and AHA1/PIP2;1 activity.

References:

• Liu C, Yu Q, Jin Y, et al. An uORF-encoded mobile peptide sparks systemic stomatal immunity[J]. Cell, 2026.

Researchers developed a cell-type-specific lysosomal atlas of the brain using LysoIP and proteomics. They identified SLC45A1 as a critical lysosomal glucose transporter in neurons. Its absence impairs lysosomal acidity, V-ATPase assembly, and metabolic recycling, linked to disease.

References:

• Ghoochani A, Heiby J C, Rawat E S, et al. Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder[J]. Cell, 2026.

Researchers developed a field-effect-informed liquid biopsy to improve MRD detection in bladder cancer. By filtering "noise" from mutations in normal tissue, this approach accurately predicts treatment outcomes. Findings show that high mutation burden and immune activation drive BCG response.

References:

• Shi W Y, Liu K J, Esfahani M S, et al. Field-effect-informed urine liquid biopsy for bladder cancer[J]. Cell, 2026.

Using the FLEXITau platform, researchers mapped 145 PTMs and 195 cleavage sites in human brains. Machine learning and mass spectrometry successfully classified six tauopathies, like Alzheimer’s, by their unique molecular signatures, offering new diagnostic and drug targets.

References:

• Kumar M, Schlaffner C N, Tang S, et al. Molecular features of human pathological tau distinguish tauopathy-associated dementias[J]. Cell, 2026.

Spatial transcriptomics (ST) maps gene expression within tissue architecture, surpassing scRNA-seq by preserving context. This review evaluates 77 platforms—from high-resolution imaging to whole-transcriptome sequencing—and 600 computational tools for analysis and multi-omics integration.

References:

• Zi-Zhen Guo, Renyan Wu, Weixiang Li, Keyu Yang, Xuexiang Ying, Hamid Alinejad-Rokny, Youqiong Ye. Mapping biology in space: from spatial transcriptomics platforms to analytical tools and databases. Science Bulletin. 2026.

Researchers used MERFISH and scRNA-seq to map the neuroimmune landscape of the mouse brain. They found that maternal immune activation and microbiome depletion disrupt fetal neurogenesis and chemokine pathways, leading to sex-specific behavioral deficits in offspring.

References:

• Kukreja B, Jeon S, Cao W, et al. Spatial transcriptomics of the developing mouse brain immune landscape reveals effects of maternal immune activation and microbiome depletion[J]. Nature Neuroscience, 2026: 1-14.

The EpiAgent web platform provides tools for cell type annotation, data mapping, and UMAP visualizations. Built on a Linux Nginx server using PHP and MySQL, it features a JavaScript-based interface for processing H5ad files and rendering complex biological charts.

References:

• Chen X, Gao Z, Li K, et al. Human-scATAC-Corpus: a comprehensive database of scATAC-seq data[J]. Nucleic Acids Research, 2026, 54(D1): D175-D183.