This scientific review article focuses on cytotoxic IgG antibodies and their role in antibody-dependent cellular cytotoxicity (ADCC), a key mechanism for depleting target cells in various diseases. The authors explore the complex molecular and cellular pathways underlying ADCC, emphasizing how factors like target cell type, effector cells, and tissue environment influence its effectiveness. The text also discusses implications for improving therapeutic strategies and provides an updated model of cytotoxic IgG activity, examining the involvement of Fcγ receptors (FcγRs), different IgG subclasses, and the specific effector cells like macrophages and NK cells that mediate these functions in various tissues and in tumor settings. Finally, the article highlights strategies for enhancing macrophage-dependent cytotoxic IgG activity and the impact of target antigen characteristics on ADCC efficacy.

References:

• Wöhner M, Nimmerjahn F. Cytotoxic IgG: Mechanisms, functions, and applications[J]. Immunity, 2025, 58(6): 1378-1395.