This paper introduces the Cancer Immunology Data Engine (CIDE), a novel computational framework that integrates thousands of omics profiles to identify secreted proteins that modulate immunotherapy responses. The authors prioritized several candidate proteins, with a particular focus on acyloxyacyl hydrolase (AOAH). Through extensive in vitro and in vivo experiments across multiple tumor models, the study demonstrates that AOAH potentiates immunotherapies by enhancing T-cell receptor sensitivity and protecting dendritic cells, primarily by depleting immunosuppressive arachidonoyl phosphatidylcholines. The research highlights the potential of AOAH as a therapeutic target to improve the effectiveness of cancer immunotherapies, while also acknowledging the need for further studies on clinical application.

References:

• Gong L, Luo J, Yang E, et al. Cancer immunology data engine reveals secreted AOAH as a potential immunotherapy[J]. Cell, 2025.