This article explores the impact of whole-genome doubling (WGD) on the evolution and immune responses in high-grade serous ovarian cancer (HGSOC). The researchers utilized single-cell whole-genome and RNA sequencing, alongside high-resolution immunofluorescence microscopy, to analyze patient tumor samples and cell lines. A key finding is that WGD is an ongoing mutational process that increases cellular diversity and chromosomal instability. The study reveals that while inflammatory signaling is activated in tumors with low WGD, WGD-high tumors develop mechanisms to suppress immune responses, including altered cell-cycle regulation and STING1 repression. These insights into WGD's role in tumor progression and immune evasion offer potential avenues for improved therapeutic strategies in HGSOC.

References:

• McPherson A, Vázquez-García I, Myers M A, et al. Ongoing genome doubling shapes evolvability and immunity in ovarian cancer[J]. Nature, 2025: 1-10.