This review article from Nature Medicine explores the future of organ transplantation, highlighting innovative strategies to overcome donor shortages and improve patient outcomes. It details how artificial intelligence (AI) is being used to optimize organ allocation, refine rejection monitoring, and personalize immunosuppressive regimens, while xenotransplantation has progressed through multi-gene editing of donor pigs to mitigate hyperacute rejection. The text also covers regenerative medicine approaches, such as stem cell therapies, 3D organoids, and bioprinting, which aim to create patient-specific tissues and reduce the need for lifelong immunosuppression. Ultimately, the article emphasizes that the integration of these technologies, coupled with ethical and regulatory frameworks, is crucial for advancing transplant medicine globally.

References:

• Loupy A, Preka E, Chen X, et al. Reshaping transplantation with AI, emerging technologies and xenotransplantation[J]. Nature Medicine, 2025: 1-13.