This research integrates 249,156 fibroblasts from 73 studies across 10 tissues to construct a comprehensive single-cell atlas of human fibroblasts. The study classifies 18 distinct fibroblast subtypes, including a previously uncharacterized TSPAN8+ chromatin remodeling fibroblast population associated with poor prognosis and specific interactions with endothelial and T cells. It explores the functional heterogeneity, tissue distribution, differentiation trajectories, aging characteristics, and clinical significance of these subtypes. The findings provide a more refined understanding of fibroblast diversity within the tumor microenvironment, including their roles in cancer progression and potential as biomarkers for targeted therapies.

References:

• Liu K, Cui Y, Han H, et al. Fibroblast atlas: Shared and specific cell types across tissues[J]. Science Advances, 2025, 11(14): eado0173.