This review article, "Linking tumour angiogenesis and tumour immunity" by Kabir et al., explores the intricate relationship between tumor angiogenesis, the formation of new blood vessels within tumors, and tumor immunity, the body's immune response to cancer. The authors discuss how the abnormal structure and function of tumor blood vessels create an immunosuppressive environment that hinders effective anti-tumor responses. They highlight the concept of vessel normalization, where anti-angiogenic therapies aim to restore normal vessel function, thereby improving immune cell infiltration and therapeutic delivery. The article also examines the synergistic potential of combining anti-angiogenic treatments with immune checkpoint blockade (ICB) therapies and identifies promising new targets beyond traditional VEGF pathways to enhance anti-angiogenic strategies and overcome treatment resistance.

References:

• Kabir A U, Subramanian M, Kwon Y, et al. Linking tumour angiogenesis and tumour immunity[J]. Nature Reviews Immunology, 2025: 1-1