In this week's episode, we take a detailed look at "Set Point Theory" and discuss how our genetics influence body shape, size and susceptibility to weight gain. While obesity is talked about almost obsessively within our society, rarely is genetics brought into the conversation, despite strong evidence of it's role. Recognising this interplay between our genes and our environment in determining body size helps us to broaden our minds as to what "health" truly means so we can foster a more compassionate approach; both within healthcare and in the relationship we have with our own bodies .

DISCLAIMER: The information discussed in this podcast are for educational and informational purposes only, and should never replace personalised advice provided by your own doctor, dietitian, or other healthcare professional.

Find me on instagram @katiewilsonrd, or check out my blog: www.saltandhoney.co.uk

REFERENCES AND SOURCES OF INFORMATION:

Twin, family and adoption studies:

https://www.nature.com/articles/ijo2011160

https://pubmed.ncbi.nlm.nih.gov/9519560/

https://academic.oup.com/ajcn/article/87/2/398/4633289

Set Point Theory:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990627/

Monogenic Obesity:

https://link.springer.com/article/10.1007/s11892-018-1053-x

https://www.nature.com/articles/nrg1556

https://academic.oup.com/edrv/article/27/7/710/2355201

GWAS-related studies and genetics in body weight:

https://pubmed.ncbi.nlm.nih.gov/18852200/

https://portlandpress.com/clinsci/article-abstract/130/12/943/71435/Recent-progress-in-genetics-epigenetics-and?redirectedFrom=fulltext

https://www.sciencedirect.com/science/article/abs/pii/S2213858717302000

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382211/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810793/

https://www.sciencedirect.com/science/article/pii/S0026049518302257

https://www.sciencedirect.com/science/article/pii/S0895398813601129

FTO gene and other specific gene variants:

https://pubmed.ncbi.nlm.nih.gov/17658951/ (FTO)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906751/ (FTO)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188449/ (FTO)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646098/ (FTO)

https://pubmed.ncbi.nlm.nih.gov/18454148/ (MC4R gene)

https://pubmed.ncbi.nlm.nih.gov/18454146/ (MC4R gene)

https://pubmed.ncbi.nlm.nih.gov/19255736/ (FTO + MC4R genes)

Behaviour change attenuates risk:

https://pubmed.ncbi.nlm.nih.gov/17942823/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635949/