Thrive State Podcast

100. Game-changing Diagnostic Test for Health, Longevity, and Performance with Ryan Smith


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Shownotes

 

Epigenetics and DNA Methylation: Changing the biggest predictor of negative health outcomes

 

  • DNA methylation is basically the switching on and off of gene expression expression. This can be used robustly in diagnostics.
  • We have genes in our DNA that based on how we live our lives and the things that we take in (that makes up our cellular environment) then put marks on our DNA (methylation tags) that basically silence some genes.

 

Assimilation and Histone Modification in Genetic Modification

 

Methylation and Biological Age Testing

 

  • DNA Methylation is now used for quantifying the body's aging process.

 

  • Biological age from methylation tests predicts longevity, aging and disease more accurately.

 

  • People who have been found to have lower biological age tend to develop less negative health outcomes while those that are older in terms of biological age tend to develop negative health outcomes more frequently and earlier.

 

Methylation and Anti-Aging

 

  • Algorithms shift the way we practice medicine. Information about our daily lives is actually encoded in our gene expression.

 

Trauma can also be also passed on through epigenetics.

 

  • Transgenerational Epigenetic Transference shows how traumatic events can change the environment of our cells to basically protect generations and how it gets passed down.

 

  • Within our conscious control, we can slowly start to break free of some of that imprinting.

 

Is de-methylation possible: In aging, yes. Some things are modifiable, some are not.

 

Epigenetics and Stress

 

  • Stress is the number one driver of CTRA and telomere shortening which is a marker for aging and disease.

 

Is methylation bad for you: There are genes that we would want to be suppressed and not. It’s not about good or bad. The more important thing is the idea and ability to methylate and the methylation factors.

Ryan's Best Medicine: Mindfulness.

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