This research reveals that HIV-1 overcomes infection barriers in resting T cells by using cell-to-cell spread to trigger internal signaling. While free-floating virus particles fail to infect these cells, direct contact between cells initiates CD4–LCK signaling, which activates the enzyme CDK1. This process remodels nuclear pores, effectively opening a gateway for the viral capsid to enter the nuc...去小宇宙查看完整单集简介
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