This research examines how mevalonate kinase deficiency (MKD), a rare autoinflammatory disorder, causes severe immune system disruptions in both humans and mice. The study identifies a critical cell-intrinsic defect where a lack of protein prenylation leads to a significant reduction in mature natural killer (NK) cells. These defective cells exhibit impaired granule trafficking and reduced cytotox...去小宇宙查看完整单集简介
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