This research identifies four unique leukemic stem cell (LSC) subtypes in acute myeloid leukemia that dictate how patients respond to the drug venetoclax. By profiling over 150 patients, the study reveals that therapy resistance is driven by the specific differentiation state and plasticity of these stem cells. A major finding is the discovery of MoDe-LSCs, a mature monocytic subtype identified by...去小宇宙查看完整单集简介
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