This paper consist of two distinct previews from the journal Cancer Cell, each focusing on recent scientific investigations related to cancer. The first source, "Tumor neutrophils rewired from birth," summarizes research indicating that tumor-derived signals systemically reprogram neutrophil development in the bone marrow, leading to immunosuppressive imprinting, but notes that IL-1β blockade can reverse this pathology and limit metastatic spread. The second source, "Drug-induced mismatch repair deficiency: Mixed prospects," discusses studies showing that chemotherapy combinations can induce mismatch repair-deficient-like phenotypes in typically mismatch repair-proficient colorectal cancers, potentially converting them into tumors more responsive to immune checkpoint inhibitors, though clinical efficacy remains uncertain. Both pieces examine new strategies for modulating the tumor microenvironment and systemic immune responses to improve cancer treatment.

References:

• Dong L, Ng L G. Tumor neutrophils rewired from birth[J]. Cancer Cell, 2025.