This research explores the essential role of VEGFR2 in the formation of lymphatic vessels, specifically during the process of sprouting. While previous understanding suggested that VEGF-C signals primarily through VEGFR3 to drive vessel growth, this study demonstrates that VEGFR2 is a critical partner required for cells to transition from simple proliferation to active sprouting. Through conditional genetic deletions in mice, the authors found that cells lacking VEGFR2 are unable to participate in the development of new capillary networks and are outcompeted by healthy cells. The findings indicate that VEGFR2 and VEGFR3 work in a coordinated fashion to balance the expansion and functional architecture of the lymphatic system. Ultimately, the study suggests that medical treatments for lymphatic disorders or cancer should target both receptor pathways to effectively control vessel growth.

References:

• Schoofs H, Zhang Y, Ortsäter H, et al. VEGFR2 is required for VEGF-C–VEGFR3–PI3Kα-mediated sprouting lymphangiogenesis[J]. Nature Communications, 2026, 17(1): 4380.

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