This research introduces APMAT-CD4, a high-throughput platform designed to identify and characterize antigen-specific CD4+ T cells at single-cell resolution. The authors developed a modular system using class II single-chain trimer libraries to overcome the technical challenges of profiling helper T cells across multiple dimensions, including TCR sequences, transcriptomes, and MHC restriction. The...去小宇宙查看完整单集简介
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