This research identifies spermine as a natural iron chelator that serves as a critical internal defense against ferroptosis, a form of iron-dependent cell death. Through metabolic profiling of hepatocellular carcinoma (HCC), scientists discovered that cancer cells exploit an alternative ALDH18A1-mediated pathway to synthesize spermine from glutamine, thereby neutralizing labile iron and preventing...去小宇宙查看完整单集简介
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