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Thinking about stopping your GLP-1 medication? You're not alone sis! Over 70% of people discontinue within two years.
In this episode, integrative clinical nutritionist (your host) Kaileigh breaks down what actually happens in your body when you stop semaglutide or tirzepatide, why weight regain is so common (spoiler: it's biology, not willpower), and the evidence-backed strategies to maintain your progress.
Learn about the strategic tapering approach, metabolic adaptation, protein targets, strength training protocols, and the psychological support that makes all the difference. Whether you hit your goal weight, couldn't afford to continue, or experienced side effects, this is your roadmap for the transition - as always without judgment, with all the science, and zero shame. Includes insights from the 2025 JAMA study of 125,000+ GLP-1 users.
Disclaimer: This is education and empowerment, not medical advice. Always work with your healthcare provider when making medication changes.
Timestamps
[06:05] The Data: What 125,000 GLP-1 Users Teach Us
[10:36] The Reinitiation Pattern: Who Restarts & Why
[15:16] What's Actually Happening in Your Body on GLP-1s
[17:40] The Metabolism Glass Analogy: Why Weight Regain Happens
[22:26] Your Body's Survival Response: Adaptive Thermogenesis
[29:39] How to Taper Off Strategically (The 2-Month Protocol)
[36:56] Strategy #1: Build Your Foundation First
[44:13] The Protein Protocol: Your New Non-Negotiable
[51:09] Movement, Sleep & Stress: The Missing Pieces
[58:22] The Emotional Work: Why You Need Support
[01:03:12] Your Action Steps & Final Reminders
Good Resources + Affiliates
Connect with Me
By Kaileigh Lauren (Coach Kailes)5
3030 ratings
Thinking about stopping your GLP-1 medication? You're not alone sis! Over 70% of people discontinue within two years.
In this episode, integrative clinical nutritionist (your host) Kaileigh breaks down what actually happens in your body when you stop semaglutide or tirzepatide, why weight regain is so common (spoiler: it's biology, not willpower), and the evidence-backed strategies to maintain your progress.
Learn about the strategic tapering approach, metabolic adaptation, protein targets, strength training protocols, and the psychological support that makes all the difference. Whether you hit your goal weight, couldn't afford to continue, or experienced side effects, this is your roadmap for the transition - as always without judgment, with all the science, and zero shame. Includes insights from the 2025 JAMA study of 125,000+ GLP-1 users.
Disclaimer: This is education and empowerment, not medical advice. Always work with your healthcare provider when making medication changes.
Timestamps
[06:05] The Data: What 125,000 GLP-1 Users Teach Us
[10:36] The Reinitiation Pattern: Who Restarts & Why
[15:16] What's Actually Happening in Your Body on GLP-1s
[17:40] The Metabolism Glass Analogy: Why Weight Regain Happens
[22:26] Your Body's Survival Response: Adaptive Thermogenesis
[29:39] How to Taper Off Strategically (The 2-Month Protocol)
[36:56] Strategy #1: Build Your Foundation First
[44:13] The Protein Protocol: Your New Non-Negotiable
[51:09] Movement, Sleep & Stress: The Missing Pieces
[58:22] The Emotional Work: Why You Need Support
[01:03:12] Your Action Steps & Final Reminders
Good Resources + Affiliates
Connect with Me

7,269 Listeners