This research article from Nature Genetics explores how the interplay between MAPK and WNT signaling pathways drives colorectal cancer development. While KRAS mutations (MAPK pathway) are typically insufficient to start intestinal tumors, the study demonstrates they induce a plastic, regenerative cell state that suppresses traditional Lgr5+ stem cells. Researchers found that tumor initiation speci...去小宇宙查看完整单集简介
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