This research identifies a critical genetic mechanism that causes mesothelioma to become resistant to CAR T cell and anti-PD-1 immunotherapies. Scientists discovered that the loss of the NF2 tumor suppressor gene triggers the activation of the Hippo pathway, which actively transforms the environment surrounding the tumor. This genetic deficiency recruits immunosuppressive myeloid cells—specificall...去小宇宙查看完整单集简介
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