From Concept to Medicine - A Comprehensive Drug Development Journey

123 - Mass Spectrometry in Drug Analysis (S9E3)


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Examine how mass spectrometry (MS) helps to generate a super detailed molecular profile in drug analysis, and in effect offers that unique fingerprint for that batch of a drug. Explore ways to identify and deal with impurities in drugs, to help ensure medication safety. Gain insight into resolution and sensitivity as it applies to the detective work in MS testing. Learn about various mass spectrometers, and how they are specially designed to solve complex analytical challenges.

Learn how identification of mysteries occurs using special processes that involve specialized knowledge to understand what a test actually means, often with detective work. This process requires comparison to libraries of known compounds and a meticulously analyzing how the molecules apart in an effort to ensure no harm is done from use of the drug. Hear how MS partners with other lab techniques, namely liquid chromatography (LC), to assist in identifying substances to ensure safety. Find out about the FDA and how they validate regulatory tests as an organization to ensure the best technology is used.

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From Concept to Medicine - A Comprehensive Drug Development JourneyBy Jim Mitchell

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