The research highlights how the integrated stress response (ISR) acts as a primary catalyst for lung adenocarcinoma evolution and therapy resistance. By studying mouse models, scientists discovered that ISR activation allows cancer cells to transition from structured lung identities into highly undifferentiated and plastic states. This genetic reprogramming is driven by the p-eIF2α–ATF4 axis, whic...去小宇宙查看完整单集简介
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