This study investigates the molecular and phenotypic mechanisms behind midostaurin resistance in FLT3-mutated acute myeloid leukemia (AML). Researchers identified a specific progenitor-like cell population marked by CD45RA and CD38 expression that facilitates survival through a signaling shift from STAT5 to PI3K/AKT. Using multi-omic profiling and functional drug testing, the authors discovered th...去小宇宙查看完整单集简介
前往小宇宙评论区与主播互动