In this episode, I share insights from a new study published in Nature Medicine: "AI-driven reclassification of multiple sclerosis progression."

🌐 Blog: https://ms-perspektive.com/128-ai-ms-reclassification

An international team of researchers analyzed data from more than 8,000 patients, 118,000 visits, and 35,000 MRI scans. With the help of artificial intelligence (AI), they discovered that MS is not best described by the traditional categories of RRMS, SPMS, and PPMS. Instead, MS should be seen as a continuum with four clinical meta-states:

1. Early / Mild / Evolving MS (EME) – stable, little disability, few brain changes

2. Asymptomatic activity – inflammation visible on MRI but without symptoms

3. Relapse – sudden worsening of symptoms

4. Advanced MS – higher disability and more brain damage

Why this matters: patients rarely move directly from early to advanced MS, but usually pass through phases of active disease first. This has major implications for treatment decisions, monitoring, and drug development.

👉 Read the full blog article here: 🔗 AI-driven reclassification of Multiple Sclerosis

🎧 Related episodes for deeper insights

• Episode 95 – Gavin Giovannoni: Smoldering MS

• Episode 50 – Tjalf Ziemssen: Future of MS treatment

These two episodes provide excellent context for understanding hidden MS activity and future treatment strategies.

See you soon and try to make the best out of your life, Nele

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