Ett kort avsnitt om riskerna med hyperoxi.

IOTA - Metanalys av 25 randomiserade studier om syrgasbehandling

Chu, D. K., Kim, L. H.-Y., Young, P. J., Zamiri, N., Almenawer, S. A., Jaeschke, R., … Alhazzani, W. (2018). Mortality and morbidity in acutely ill adults treated with liberal versus conservative oxygen therapy (IOTA): a systematic review and meta-analysis. The Lancet, 391(10131), 1693–1705. https://doi.org/10.1016/S0140-6736(18)30479-3

AVOID

Stub, D., Smith, K., Bernard, S., Nehme, Z., Stephenson, M., Bray, J. E., et al. (2015). Air Versus Oxygen in ST-Segment Elevation Myocardial Infarction. Circulation. http://doi.org/10.1161/CIRCULATIONAHA.114.014494

IVA-studie från Italien

Girardis M, Busani S, Damiani E, Donati A, Rinaldi L, Marudi A, Morelli A, et al. (2016). Effect of Conservative vs Conventional Oxygen Therapy on Mortality Among Patients in an Intensive Care Unit: The Oxygen-ICU Randomized Clinical Trial. JAMA. 2016 Oct 18;316(15):1583-1589.

Hyperoxi på akuten leder till ökad mortalitet

Page et al. (2018) Emergency department hyperoxia is associated with increased mortality in mechanically ventilated patients: a cohort study. Critical Care  (2018) 22:9 DOI 10.1186/s13054-017-1926-4