This article reports on a scientific study demonstrating that oral vitamin C supplementation delays ovarian aging in non-human primates. The authors conducted a multi-year experiment in cynomolgus macaques, finding that vitamin C diminished common aging markers such as oxidative stress and follicular depletion. Utilizing advanced single-cell transcriptomic analysis, the research revealed that vitamin C had a rejuvenating effect on both oocytes and somatic cells, effectively reducing their predicted biological age. Mechanistically, the study suggests that these geroprotective benefits are partly mediated by the activation of the NRF2 antioxidant pathway, positioning vitamin C as a potentially translatable strategy for combating reproductive aging.

References:

• Jing Y, Lu H, Li J, et al. Vitamin C conveys geroprotection on primate ovaries[J]. Cell Stem Cell, 2025.