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Key Moments:

0:00 Introduction

1:12 Journey from Electrical Engineering to Neuroscience

6:45 Initial Interest in Neuroscience 

8:16 What is connectomics?

11:45 Parallels Between Microchip Design and Neuroscience 

14:22 Probabilistic Reconstruction in Connectomics

19:46 Neurons Behaving Like Brain Regions In C. Elegans

22:17 Incorporating Biological Knowledge into Reconstruction Models and Techniques

25:47 Humans vs ML: Neuron Image Classification 

28:05 Future of Connectomics

31:20 Expansion Microscopy

33:19 Genetic Barcoding

34:25 Synchrotrons and X-Rays

34:56 Combining Techniques 

35:52 Connectomics: From Flies to Larvae Zebrafish - Optical Microscopy

37:19 Bee Neuroscience, Behavior, and Connectomics

40:03 Mouse Connectomics: Eventually Expansion and Exploration of More Complex Animal Brains

42:39 Any Possibility to Understand the Human Brain at this Level of Detail?

45:07 Tips for Breaking into Connectomics and Neuroscience 

50:50 Why are gap junctions hard to see?

53:48 Connectomics Applied to Neuromorphic Computing

55:07 Alcoholic Fruit Flies: Connectomics Applied to Human Medicine

58:03 Conclusion and Contact Info

Dr. Scheffer’s email: [email protected]

Recorded: 3/20/2024

Host: Robert Murcko