This is a review article from Nature Cell Biology that systematically explores translational regulation in the context of cellular stress biology and aging. The authors focus on how three age-associated stressors—loss of proteostasis, oxidative damage, and dysregulated nutrient sensing—modify protein synthesis. The text details the specific molecular mechanisms by which cells sense these stresses and implement corresponding adaptive or, at times, deleterious translational programs, such as activating the Integrated Stress Response (ISR) or inhibiting mTORC1 signaling. Ultimately, the review compares the translational changes observed during acute stress responses with the patterns of protein synthesis alterations that occur during healthy and unhealthy aging to better understand longevity.

References:

• Genuth N R, Dillin A. Translational regulation in stress biology[J]. Nature Cell Biology, 2025: 1-13.