Azithromycin is a macrolide antibiotic used to treat many bacterial infections. Some common uses are for Community Acquired Pneumonia (CAP), Group A Strep, Acute Exacerbations of COPD, STDs, among other bacterial infections. One of the most commonly known dosing regimens is 500 mg on day one, then 250 mg on days 2-5. When using the reconstituted suspension it must be refrigerated once reconstituted it must be discarded after 10 days. Azithromycin works through the inhibition of RNA-dependent protein synthesis by binding to the 50S ribosomal subunit. By blocking transpeptidation this inhibits the chain elongation step of protein synthesis. Azithromycin distributes well into most tissues and fluids with the exception of cerebrospinal fluid (CSF). Protein binding is concentration dependent varying from 7-51%. Azithromycin can be taken with or without food but food may decrease any GI distress. 

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