This study introduces a comprehensive human vascular cell atlas that maps the molecular profiles of endothelial and mural cells across various organs and tissues. By utilizing single-cell RNA sequencing and spatial transcriptomics, the researchers identified significant functional diversity and tissue-specific adaptations within the circulatory system. Their findings highlight how specialized cells, such as those in the brain-blood barrier or the splenic littoral system, possess unique genetic signatures. The researchers also employed a tool called drug2cell to predict how specific medications might interact with different vascular beds, offering insights into both therapeutic targeting and potential side effects. Ultimately, this open-access resource serves as a foundational reference for understanding vascular health and the progression of diseases like cancer and hypertension.

References:

• Barnett, S.N., Cujba, AM., Yang, L. et al. An organotypic atlas of human vascular cells. Nat Med 30, 3468–3481 (2024). doi.org