Researchers have developed a biohybrid microrobot named EcN@PDA@HP to improve the treatment of inflammatory bowel disease (IBD). This system utilizes stress-trained microalgae that produce a potent antioxidant while developing a thickened cell wall to survive harsh stomach acids. By attaching probiotics coated in a specialized adhesive layer, the robots can rapidly traverse the gut and "brake" at inflamed sites for targeted therapy. Studies in murine models demonstrate that these robots effectively scavenge harmful reactive oxygen species and restore a healthy microbial balance in the intestines. Ultimately, this dual-action approach offers a promising, biocompatible strategy for managing chronic digestive inflammation through active drug delivery.

References:

• Luo R, Liu J, Dai L, et al. Stress-trained microalgae robots with probiotics backpack and intestinal brake for inflammatory bowel disease management[J]. Nature Communications, 2026.