Quetiapine is also known by the brand name Seroquel. It comes as both an immediate release and extended release formulation. There are several indications such as for schizophrenia and various classifications of Bipolar disorder. It can also be used as adjunct treatment in major depressive disorder. The max dose for quetiapine is 800 mg/day. Doses are generally divided bid-tid. Quetiapine’s antipsychotic activity is proposed to be a result of both dopamine type 2 (D2) and serotonin type 2 (5HT2) antagonism. There are many other antagonist effects on neurotransmitter receptors in the brain such as 5HT1A, 5HT2, D1, D2, H1, and adrenergic alpha1/alpha3 receptors. There is a black box warning for dementia related psychosis and suicidality. Common side effects are somnolence, weight gain, and constipation. Quetiapine should never be stopped abruptly after prolonged usage. 

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