I sit down with my co-host Reiss to break down different decentralized production models - 3D printing, mini-mills, upcycling, and bio-manufacturing - and dive deeper into the world of bio-manufacturing. We explore how biology can create much more decentralized, cleaner forms of production and discuss the following topics:

* Decentralized production methods: 3D Printing, Mini Mills, Upcycling, & Bio-manufacturing.

* How synthetic biology uses sugar instead of petroleum to create all types of products.

* The large infrastructure gap between high-value pharmaceuticals and lower-value Industrial biotech.

* Importance of “sterility” in scaling bio-manufacturing.

* Using insects as living bioreactors to produce proteins.

* Advancements in trait-modified crops.

* What’s needed to make bio-based products cost-competitive.

Enjoy!Watch on Youtube, Spotify or Apple Podcasts

Recording date: November 14, 2025

Chapters:

00:00 Introduction

01:30 Decentralized Production Breakdown

09:31 Explaining How Bio-manufacturing Works

12:29 Important Role Of Feedstocks

14:32 Pharma vs. Industrial Biotech

18:17 Challenges In Scaling Bio-manufacturing

23:55 Using Insects As Bioreactors

28:55 Infrastructure Needed To Make Industrial Biotech Competitive

33:06 Trait Modified Crops & Decentralized Farming

35:58 Decentralizing Crop Production

36:56 Cell-Based Chocolate Example

42:23 Scaling Laws in Industrial Biotech

51:18 Other Advancements In Crop Modification

53:18 Bio-manufacturing Wishlist

Follow Jordan on X

* https://x.com/jrwolfe

Resources Mentioned:

* California Cultured (Cell-based Chocolate/Coffee) – https://www.cacultured.com/

Remember to go direct!Jordan

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