The ADAPT initiative, launched by ARPA-H, aims to modernize oncology by shifting from static treatments to a dynamic, evolution-based care model. This national program utilizes interpretable artificial intelligence and multimodal data to predict how tumors will change and develop resistance in near real time. By integrating longitudinal biomarkers with an innovative evolutionary clinical trial framework, the system allows doctors to adjust therapies as a patient’s cancer mutates. A centralized Treatment and Analysis Platform facilitates the rapid sharing of clinical insights across institutions to ensure treatments remain ahead of disease progression. Ultimately, the program seeks to improve survival rates for metastatic cancers by making precision medicine more responsive to the biological shifts of each tumor.

References:

• Bild A H, Sangar M C, McQuerry J A, et al. The ADAPT learning cancer treatment system: ARPA-H’s initiative to revolutionize cancer therapy[J]. Cancer Cell, 2026.