Researchers used CRISPR screening to identify neddylation as a vital regulator of neuronal aging. Blocking this pathway in stem cell-derived neurons triggers senescence, DNA damage, and proteostasis failure. These age-related hallmarks drive Tau pathology and cell death.

References:

• Genome-wide CRISPR screen identifies neddylation as a regulator of neuronal aging and AD neurodegeneration
• Saurat, Nathalie et al.Cell Stem Cell, Volume 31, Issue 8, 1162 - 1174.e9