Yu et al. mapped human pancreatic gene co-expression networks (GCNs) to improve stem cell-derived β cell induction. Existing protocols fail to mimic in vivo GCNs, but a new 19-day strategy restores this architecture. This approach yields 70% functional β cells that reverse diabetes.

References:

• Yu X X, Wang X, Yang L, et al. Reconstructing human pancreatic gene networks enhances stem cell-derived β cell induction[J]. Developmental Cell, 2025.