Oof. Ouch. That pounding pain at the temples. That throbbing at the base of the neck. Yep, it's a headache, and it is excruciatingly painful. The first thing we might do is head to the medicine cabinet and grab a bottle of ibuprofen or acetaminophen, but what if the stash is completely empty? Is there any way to get fast relief? Have no fear, because we've found some of the best ways to put an end to headache pain. 1.