This research maps the mouse kidney's spatial and regulatory landscape across ages and sexes. It identifies sex-biased gene expression emerging during puberty, driven by hormonal pathways like PRLR/JAK/STAT. It also highlights aging-related changes and their links to human disease.

References:

• Chen S, Liu R, Mo C K, et al. Multi-omic and spatial analysis of mouse kidneys highlights sex-specific differences in gene regulation across the lifespan[J]. Nature Genetics, 2025: 1-15.