Research identifies macrophages as the primary antigen-presenting cells for MAIT cells. High MR1 expression allows these macrophages to capture vitamin B-derived antigens from the microbiota. This interaction is vital for antimicrobial immunity and lung homeostasis.

References:

• Deng J, Yan Y, Zhang X, et al. Macrophage MR1 antigen presentation promotes MAIT cell immunity and lung microbiota modulation[J]. Science, 2025, 391(6782): eadr6322.