Researchers analyzed the plasma proteome of continental Africans to understand type 2 diabetes (T2D). They identified 399 pQTLs, many unique to African ancestry. Results highlight 18 proteins, including ACE and SIRPα, as causal drivers or therapeutic targets for T2D.

References:

• Soremekun O, Park Y C, Tutino M, et al. Linking the plasma proteome to genetics in individuals from continental Africa provides insights into type 2 diabetes pathogenesis[J]. Nature Genetics, 2026: 1-8.