Researchers developed rhesus macaque placental organoids to model primate pregnancy. Using RNA sequencing, they found these models mirror in vivo development. Comparison with human organoids reveals shared syncytiotrophoblast programs but divergent extravillous trophoblast signatures.

References:

• Comparative analysis of rhesus macaque and human placental organoids highlights evolutionary differences in placentationCaldwell, Allyson et al.Developmental Cell, Volume 0, Issue 0