Python in 2025 is different. Threads really are about to run in parallel, installs finish before your coffee cools, and containers are the default. In this episode, we count down 38 things to learn this year: free-threaded CPython, uv for packaging, Docker and Compose, Kubernetes with Tilt, DuckDB and Arrow, PyScript at the edge, plus MCP for sane AI workflows. Expect practical wins and migration paths. No buzzword bingo, just what pays off in real apps. Join me along with Peter Wang and Calvin Hendrix-Parker for a fun, fast-moving conversation.

Seer: AI Debugging, Code TALKPYTHON

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Links from the show

Calvin Hendryx-Parker: github.com/calvinhp

Peter on BSky: @wang.social

Free-Threaded Wheels: hugovk.github.io

Tilt: tilt.dev

The Five Demons of Python Packaging That Fuel Our ...: youtube.com

Talos Linux: talos.dev

Docker: Accelerated Container Application Development: docker.com

Scaf - Six Feet Up: sixfeetup.com

BeeWare: beeware.org

PyScript: pyscript.net

Cursor: The best way to code with AI: cursor.com

Cline - AI Coding, Open Source and Uncompromised: cline.bot

Watch this episode on YouTube: youtube.com

Episode #524 deep-dive: talkpython.fm/524

Episode transcripts: talkpython.fm

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