Precise DNA replication depends on the S-phase checkpoint and PCNA dynamics. Research shows PAF15 acts as a "toolbelt" anchor, coordinating Okazaki fragment processing by preventing steric clashes between enzymes. ATR inhibition causes excessive origin firing, exhausting resources.
References:
* Chhetri G, Badugu S B, Petriman N A, et al. PAF15–PCNA exhaustion governs the strand-specific control o...去小宇宙查看完整单集简介
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