Researchers used MERFISH and scRNA-seq to map the neuroimmune landscape of the mouse brain. They found that maternal immune activation and microbiome depletion disrupt fetal neurogenesis and chemokine pathways, leading to sex-specific behavioral deficits in offspring.

References:

• Kukreja B, Jeon S, Cao W, et al. Spatial transcriptomics of the developing mouse brain immune landscape reveals effects of maternal immune activation and microbiome depletion[J]. Nature Neuroscience, 2026: 1-14.